Wednesday, 30 November 2011

Patricia Cornwell: 'Powerful women are more likely to kill'

It isn?t giving too much away to reveal that all of the criminals in Patricia Cornwell?s new book ? and there are several ? are female. There is one who hammers nails into a child?s head, another who is a convicted sex offender, and a woman on death row for murdering a family as they slept. Then there is the mother who smothers her children and ? my personal favourite ? the woman who condemns her victims to long and painful deaths by Botox (she injects food with the botulinum toxin). Meanwhile, men are reduced to mere walk-on roles, emasculated, castrated ? not literally, though this process does appear in other Cornwell novels ? and cast as helpless husbands and ineffectual police officers.

Red Mist is Cornwell?s 19th Scarpetta novel, the one that will nudge her over the magical 100 million copies mark. It is also the book that coincides with her work finally hitting the big screen. Angelina Jolie has signed up to play Cornwell?s protagonist, Dr Kay Scarpetta, a former chief medical examiner of the state of Virginia and forensic consultant.

In previous novels Scarpetta has dealt with sexual sadists and serial killers who leave limbless corpses, but none have featured quite so many female psychopaths. The main killer in Red Mist poisons her victims, which Cornwell tells me ?is very female?. She says this in a cool, clinical manner, matter-of-factly, as if poisoning people was the most natural thing a woman could do after having periods and growing breasts (I suppose this detachment must be what happens when you have worked in a morgue, spent much of your time shadowing forensics experts and frequently attended autopsies, as Cornwell has.) ?[Poisoning is] a long, drawn-out death, so it?s diabolical, sadistic, psychological, which is a female thing. It?s an inversion of the maternal instinct to nurture.? Cornwell stirs her green tea with a manicured hand, served to her in the Savoy?s finest china.

Female killers being reasonably rare ? rare enough for us to be amazed when Rose West or Myra Hindley were convicted and react hysterically when Amanda Knox was first placed under suspicion ? it seems a bit much that there would be as many as four within the pages of one book. ?Well, I think what you are going to see as society evolves is a lot less distinction between the crimes males and females commit,? says Cornwell when I mention this. ?Murder is about power and the more powerful women get the more it will change the good that they do and the bad that they do. Equality will change our behaviour. I mean, we tend to do what we can get away with.?

Perhaps we should see Red Mist as a particularly twisted piece of feminist literature that says ?Hey boys, you may be good at killing, but us women can murder too!?, and view Patricia Cornwell as a modern-day Germaine Greer let loose in a city morgue. Certainly, if a cartoonist was to draw a feminist, then they would probably come up with someone who looks a bit like Cornwell: she flies helicopters, keeps guns, is married to a woman and ostensibly cuts a tough figure ? today she is wearing cowboy boots, leather jacket, ripped jeans and a belt with a pirate skull on the buckle (she collects skulls ? of course she does).

Source: http://telegraph.feedsportal.com/c/32726/f/568409/s/1a7d1e50/l/0L0Stelegraph0O0Cculture0Cbooks0C89216140CPatricia0ECornwell0EPowerful0Ewomen0Eare0Emore0Elikely0Eto0Ekill0Bhtml/story01.htm

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Brain electric shocks used to treat Alzheimer's

Alzheimer?s disease could be eased by ?the return of electric shock therapy?, the Daily Mail reported.

This story is based on a small safety trial that tested a technique called ?deep brain stimulation? (DBS) in six patients with Alzheimer?s disease. The technique involves surgically implanting electrodes into the patients? brains and delivering a series of electric pulses to the targeted brain region. However, although some patients showed slight improvements, the researchers? objective was to test the safety of the technique, not whether it offered an effective treatment for Alzheimer?s. Therefore, they cannot confirm how DBS interacts with this complex disease or whether it does produce improvements.

The mild stimulation used in DBS is not to be confused with electroconvulsive therapy (ECT), or ?shock therapy?, which is itself a valuable technique for helping some patients with severe depression. To explore their DBS technique further, the researchers are now conducting larger human trials and animal research, the results of which will show more clearly whether DBS could be used as a treatment.

Where did the story come from?

The study was carried out by researchers from the University of Toronto, the University of Zurich and Johns Hopkins University, Maryland. The research was supported by the Neurological Research and Education Foundation, the Dana Foundation and the Krembil Neuroscience Discovery Fund.

The original human trial was published in the�peer-reviewed journal Annals of Neurology. The follow-up mouse study was published in the Journal of Neuroscience.

This study was reported accurately by the media. The Daily Mail appropriately outlined the limitations of the study, including the preliminary and small-scale nature of the research. However, the technique used in this study was not ?electric shock therapy?; it was the use of an electrical device implanted directly into the brain to stimulate certain regions mildly.

What kind of research was this?

This clinical study examined the effect of deep brain stimulation (DBS) on the size and functioning of an area of the brain called the hypothalamus, which is involved in memory. The researchers thought that stimulating this area of the brain with electric pulses could alter the activity of the memory circuits in patients with early Alzheimer?s disease (AD).

This was a phase one clinical study, designed to test the safety of a new therapy. These trials are generally small, as the goal is to make sure that the method is acceptable to use in larger trials, and not to precisely define its effectiveness. Only once phase one trials have determined that a technique is safe can larger studies be conducted to determine how effective the technique is in a broader patient population.

What did the research involve?

The researchers recruited six patients who had been diagnosed with Alzheimer?s within the previous two years. All were receiving medication for the disease. The researchers surgically placed electrodes in the patients? brains. The electrodes delivered a small electric pulse to the hypothalamus, and the therapy was used alongside the patients? existing medication for one year. The researchers measured changes in the activity of various brain structures, the brain?s use of sugar (which has previously been shown to be reduced in patients with AD), and cognitive function at 1, 6 and 12 months after surgery.

To measure changes in the brain?s mental and physical functioning, the researchers used the following techniques:

  • standardised low-resolution electromagnetic tomography (sLORETA), to map the brain and determine which regions were activated by the therapy
  • an imaging technique called positron emission tomography (PET), to measure use of glucose in these specific brain regions
  • the mini-mental state examination (MMSE) and the Alzheimer?s disease assessment scale (ADAS), to measure functional changes and the severity and progress of the disease ?�these accepted clinical assessments measure things such as memory and language function

The researchers took all three measurements at the start of the study (the ?baseline?) and after 1, 6 and 12 months of deep brain stimulation treatment. They compared the post-surgery measures to the baseline measures to assess the effect of the therapy on structural, functional and clinical outcomes.

What were the basic results?

When assessing changes in patient functioning, as measured by the MMSE and ADAS, the researchers found that, compared to baseline measures:

  • After one month of DBS, three patients showed slight improvement in functioning and three patients showed a slight worsening of functioning.
  • After six months of DBS, four patients showed improvement in functioning and two showed either no change or worsening of functioning.
  • After 12 months of DBS, one patient showed an improvement, and five showed a worsening of functioning.

When these results were compared to the expected change in functioning over one year of a typical patient with Alzheimer?s disease, it was found that two of the participants had a less severe decline in functioning than expected, one had a more severe decline than expected, and three had a similar change in functioning as expected.

The researchers mapped the areas of the brain that were affected by the DBS treatment. In addition to the areas being directly stimulated by DBS, regions involved with the brain?s memory circuit were consistently activated in all six patients. The researchers say this demonstrates that stimulation of the hypothalamus drives the activity of the brain?s memory circuit.

When the researchers measured brain activity (in terms of the brain?s use of sugar), they found that after both 1 and 12 months of DBS, all patients demonstrated increased activity in the brain areas affected by Alzheimer?s disease, compared to before treatment. In patients with Alzheimer?s disease, sugar use would be expected to decrease as brain activity declined.

How did the researchers interpret the results?

The researchers concluded that deep brain stimulation (DBS) produces ?striking and sustained changes? in the activity of brain regions that are typically dysfunctional in patients with Alzheimer?s disease. They said that the technique was also shown to be safe.

Conclusion

This was a small, early-stage clinical study that tested the safety of using deep brain stimulation to treat Alzheimer?s disease. Due to the preliminary nature of this research and the fact it did not compare DBS patients against a control group, the results can?t be universally applied to all patients with Alzheimer?s disease. The researchers have since started a larger-scale study (involving 50 people) to assess the benefits and effectiveness of the treatment.

Potential issues with this sort of study are:

  • Without a control group it isn?t possible to say that any slowing of the deterioration expected in people with Alzheimer?s was due to the treatment. It isn?t valid to compare the results from so few people with an ?expected? rate of decline.
  • The patients involved in this study were all in the early stages of the disease. The researchers said that having a particular memory circuit still functioning appears to be associated with how well people respond to DBS. As such, use of this therapy in patients with more advanced disease may not be possible. Undergoing this type of surgery may also be distressing or confusing for people who have lost some mental function.
  • The process involves invasive brain surgery, and factors such as age-related illnesses may make the technique unsuitable for some people even if they are in the early stage of the disease.
  • This study demonstrated the potential therapeutic benefit of this technique in patients in the early stages of the disease, but was unable to define the mechanism through which DBS may generate the changes seen. A follow-up study in mice showed that DBS resulted in the generation of new cells in another part of the brain involved in memory: the hippocampus.

Alzheimer?s is a complicated disease, and we don?t yet fully understand its underlying cause or precisely how all the observed dysfunctions fit together. The researchers acknowledged that they do not know how this treatment works, if it does at all. This research may prove to be a springboard for identifying new treatment options of this disease or, as with many exploratory ventures, it could prove to be ineffective.

Links To The Headlines

The return of electric shock therapy? Alzheimer's 'could be eased by bursts of electricity to the brain'. Daily Mail, November 23 2011

Links To Science

Stone SS, Teixeira CM, Devito LM et al. Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. Journal of Neurology 2011;31:13469-13484

Laxton AW, Tang-Wai DF, McAndrews MP et al. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Annals of Neurology 2010;68:521?534

Source: http://www.nhs.uk/news/2011/11November/Pages/brain-electric-shock-therapy-for-alzheimers.aspx

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The Most Common Vaginal Infection

Vaginosis or vaginitis is an inflammation which occurs in the vagina and includes several strains of germ that cause bacterial vaginosis yeast infections and trichomoniasis. Many women mistakenly believe that yeast infections are the most common type of vaginal infection but bacterial vaginosis is the most frequently occurring vaginal infection affecting from 10% to 64% of the population at any given time.

A simple list of symptoms of the most common vaginal infection--bacterial vaginosis. Includes articles that explore other vaginal infections, as well as diagnosis, treatment, and prevention of bacterial vaginosis.

Source: http://womenshealth.about.com/b/2011/11/16/the-most-common-vaginal-infection-5.htm

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The Dangers Of Snow Shoveling

Main Category: Heart Disease
Also Included In: Men's health;��Public Health
Article Date: 28 Nov 2011 - 0:00 PST

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Urban legend warns shoveling snow causes heart attacks, and the legend seems all too accurate, especially for male wintery excavators with a family history of premature cardiovascular disease. However, until recently this warning was based on anecdotal reports.

Two of the most important cardiology associations in the US include snow -shoveling on their websites as a high risk physical activity, but all the citation references indicate that this warning was based one or two incidents.

"We thought that this evidence should not be enough to convince us that snow-shoveling is potentially dangerous, " says Adrian Baranchuk, a professor in Queen's School of Medicine and a cardiologist at Kingston General Hospital.

Dr. Baranchuk and his team retrospectively reviewed KGH patient records from the two previous winter seasons and discovered that of the 500 patients who came to the hospital with heart problems during this period, 7 per cent (35 patients) had started experiencing symptoms while shoveling snow.

"That is a huge number," says Dr. Baranchuk. "7 per cent of anything in medicine is a significant proportion. Also, if we take into account that we may have missed some patients who did not mention that they were shoveling snow around the time that the episode occurred, that number could easily double."

The team also identified three main factors that put individuals at a high risk when shoveling snow. The number one factor was gender (31 of the 35 patients were male), the second was a family history of premature coronary artery disease (20 of the 35 patients), and the third was smoking (16 out of 35 patients). The second two factors may carry much more weight than the first, however, since the team could not correct for high rate of snow shoveling among men in their sample.

A history of regularly taking four or more cardiac medications was found to be preventative.

Dr. Baranchuk collaborated on this study with Wilma Hopman (Department of Community Health and Epidemiology, KGH Clinical Research Centre), William McIntyre, (Queen?s medical resident), and Salina Chan and David Schogstad-Stubbs (Queen?s medical students).
These findings were recently published in Clinical Research in Cardiology.
Queen's University
Please use one of the following formats to cite this article in your essay, paper or report:

MLA

Queen's University. "The Dangers Of Snow Shoveling." Medical News Today. MediLexicon, Intl., 28 Nov. 2011. Web.
30 Nov. 2011. <http://www.medicalnewstoday.com/releases/238210.php>


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Source: http://www.medicalnewstoday.com/releases/238210.php

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Time To Say "Goodbye"

After 14 years as your About.com Women's Health Guide, the time has come for me to say "goodbye." It's time for me to explore the many other options that have been available to me for a long time. However, it is with great sadness that I leave all of you who I have come to know over the years. Thank you all for the wonderful friendships, and kind words you've written to me over the years.

The good news is my content will remain here for your use when you need it.

Please feel free to contact me, as I continue my writing career. I will still love talking with you about your health issues, and help you in any way I can. So, it's so long for now, until we meet again somewhere down the road.

Take care,

Tracee

Source: http://womenshealth.about.com/b/2011/11/30/time-to-say-goodbye.htm

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Kidney Stones


Suggested Reading on Kidney Stones by Our Doctors

    • Urinary Tract Infection (UTI In Adults)
      • Urinary tract infection (UTI) is an infection of the kidney, ureter, bladder, and/or urethra. Not everyone with a UTI has symptoms. Common symptoms include a frequent urge to urinate and a painful, burning when urinating.
    • Abdominal Pain
      • Abdominal pain is pain in the belly and can be acute or chronic. Causes include inflammation, distention of an organ, and loss of the blood supply to an organ. Abdominal pain can reflect a major problem with one of the organs in the abdomen such as the appendix, gallbladder, large and small intestine, pancreas, liver, colon, duodenum, and spleen.
    • High Blood Pressure
      • High blood pressure, also known as hypertension, is a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90. There are two causes of high blood pressure, primary and secondary. Primary high blood pressure is much more common that secondary and its basic causes or underlying defects are not always known. It is known that a diet high in salt increases the risk for high blood pressure, as well as high cholesterol. Genetic factors are also a primary cause. Secondary high blood pressure is generally caused by another condition such as renal hypertension, tumors, and other conditions. Treatment for high blood pressure is generally lifestyle changes and if necessary, diet.
    • Gout
      • Gout is a condition that results from crystals of uric acid depositing in tissues of the body. Gout is a condition that can lead to abnormally elevated levels of uric acid in the blood, recurring attacks of joint inflammation (arthritis), deposits of hard lumps of uric acid in and around the joints, and decreased kidney function and kidney stones.
    • Lower Back Pain
      • There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
    • Diabetes (Type 1 and Type 2)
      • Diabetes mellitus is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
    • Dehydration
      • Dehydration is the excessive loss of body water. There are a number of causes of dehydration including heat exposure, prolonged vigorous exercise, and some diseases of the gastrointestinal tract. The best way to treat dehydration is to prevent it from occurring.
    • Kidney Infection
      • Kidney infection (pyelonephritis) usually is caused from bacteria that have spread from the bladder from a UTI (urinary tract infection), poor hygiene, sexual intercourse, pregnancy, catheter, cystoscope exam, surgery, kidney stones, or prostate enlargement. Symptoms of kidney infection include: back pain, frequent urination, pain during urination, fever, and or pus or blood in the urine. Kidney infection is usually treated with antibiotics.
    • Nausea and Vomiting
      • Nausea is an uneasiness of the stomach that often precedes vomiting. Nausea and vomiting are not diseases, but they are symptoms of many conditions. The causes of vomiting differ according to age, and treatment depends upon the cause of nausea and vomiting.
    • Fever
      • Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.). Fever is part of the body's own disease-fighting arsenal: rising body temperatures apparently are capable of killing off many disease- producing organisms.
    • Blood in Urine
      • Blood in the urine is termed hematuria. Hematuria, whether it be gross or microscopic, is abnormal and should be further investigated.
    • Polycythemia (High Red Blood Cell Count)
      • Polycythemia (elevated red blood cell count) causes are either primary (aquired or genetic mutations) or secondary (diseases, conditions, high altitude). Treatment of polycythemia depends on the cause.
    • Blood In Semen
      • Blood in semen is also known as hematospermia. Blood in semen can be caused by many conditions affecting the tubes that distribute semen from the testicles (seminal vesicles) or the prostate gland. Symptoms that may accompany blood in semen include blood in the urine, fever, painful urination, pain with ejaculation, tenderness, and swelling in the testes or groin area. Urinalysis, ultrasound, and MRI may be used to diagnose blood in the semen. Treatment depends upon the underlying cause of blood in the semen.
    • Inflammatory Bowel Disease (Intestinal Problems of IBD)
      • The inflammatory bowel diseases (IBD) are Crohn's disease (CD) and ulcerative colitis (UC). The intestinal complications of Crohn's disease and ulcerative colitis differ because of the characteristically dissimilar behaviors of the intestinal inflammation in these two diseases.
    • Bladder Infection
      • E. coli is the most common cause of bladder infections. Bladder infection symptoms and signs include frequent urination, burning urination, and foul smelling urine. Mild bladder infections may go away by increasing one's intake of fluid. More severe infections may be treated with a few days of antibiotics.
    • Testicular Pain (Pain in the Testicles)
      • Testicular pain, or pain in the testicle or testicles are caused by a variety of diseases or conditions such as testicular trauma, testicular torsion, testicular cancer, epididymitis, and orchitis. Common symptoms of pain in the testicle or testicles are abdominal pain, urinary pain or incontinence, fever, nausea, vomiting, and pain in the scrotum or testicle. Treatment depends on the cause of the testicular pain or pain in the testicles.
    • Hydronephrosis
      • Hydronephrosis is a condition in which the kidney swells, due to a backup of urine. Hydronephrosis generally occurs with another disease.Symptoms of hydronephrosis include nausea, vomiting, urinary tract infection, fever, painful urination, increased urinary frequency and urgency, flank pain, and swelling of the abdomen. Treatment of hydronephrosis depends on the cause.
    • Hyperparathyroidism
      • Hyperparathyroidism is a disorder of the parathyroid glands. There are two types of hyperparathyroidism, primary and secondary. When the parathyroid glands produce too much hormone, hyperparathyroidism is the resulting condition. Most cases of hyperparathyroidism have no evident cause. Symptoms include fatigue, weakness, depression, loss of appetite, nausea, vomiting, constipation, or confusion. Increased calcium and phosphorous excretion may cause kidney stones. The main treatment of hyperparathyroidism is parathyroidectomy.
    • Hypercalcemia (Elevated Calcium Levels)
      • Hypercalcemia is a condition in which calcium levels in the blood are elevated. Hypercalcemia is associated with other conditions such as hyperparathyroidism, lung cancer, breast cancer, kidney failure, and elevated levels of vitamin D. Symptoms of hypercalcemia include constipation, nausea, abdominal pain, kidney stones, to name a few. Treatment depends on the cause of hypercalcemia.
    • Cystinuria
Patient to Patient

The Agony of Kidney Stones

One Patient's Story

Learn about the signs, symptoms, causes, and treatment of kidney stones.By Angela Generoso
MedicineNet.com

Reviewed by William Shiel Jr., MD, FACP, FACR

It all started on a typical Maui fall day, with beautiful trade winds and sunny skies over the Kapalua Golf Course. Tom Stokes* and his wife Teresa* were about to start the ninth hole when Tom had to go to the bathroom.

"I was standing over the urinal and noticed blood in my urine," Stokes says.

Confused as to what he should do, Stokes decided to just finish playing golf without mentioning anything to his wife.

"Needless to say, I didn't have a good score from that point on," he says.

Back at the hotel he was still urinating blood, but decided it could wait until he returned home to California the following day.

"There were no other symptoms," he says. "No pain, no other indications."

Upon returning to California, Stokes went to see a urologist who asked him to have a kidney ureter bladder (KUB) x-ray done, which documented that he had a kidney stone.

Stokes' stone was so big it couldn't pass from the kidney to the ureter (the tube from the kidney to the bladder). The stone was approximately 8 mm, while the average inner diameter of the ureter is 4 mm.

*Names have been changed.


Patient to Patient

Kidney stone facts

  • A kidney stone is a hard, crystalline mineral material formed within the kidney or urinary tract.
  • Nephrolithiasis is the medical term for kidney stones.
  • Symptoms of a kidney stone include flank pain (which can be quite severe) and blood in the urine (hematuria).
  • Kidney stones form when there is a decrease in urine volume and/or an excess of stone-forming substances in the urine.
  • Dehydration is a major risk factor for kidney stone formation.
  • People with certain medical conditions, such as gout, and those who take certain medications or supplements are at risk for kidney stones.
  • Dietary and hereditary factors are also related to stone formation.
  • Diagnosis of kidney stones is best accomplished using a CT scan.
  • Most kidney stones will pass through the ureter to the bladder on their own with time.
  • Treatment includes pain-control medications and, in some cases, medications to facilitate the passage of urine.
  • If needed, lithotripsy or surgical techniques may be used for stones which do not pass through the ureter to the bladder on their own.

What is a kidney stone?

A kidney stone is a hard, crystalline mineral material formed within the kidney or urinary tract. Kidney stones are a common cause of blood in the urine (hematuria) and often severe pain in the abdomen, flank, or groin. Kidney stones are sometimes referred to as renal calculi.

The condition of having kidney stones is termed nephrolithiasis. Having stones at any location in the urinary tract is referred to as urolithiasis, and the term ureterolithiasis is used to refer to stones located in the ureters.

Kidney Stones
(Renal Stones, Nephrolithiasis)

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Kidney Stones

What is polycythemia?

Polycythemia is a condition that results in an increased level of circulating red blood cells in the bloodstream. People with polycythemia have an increase in hematocrit, hemoglobin, or red blood cell count above the normal limits.

Polycythemia is normally reported in terms of increased hematocrit or hemoglobin.

  • Hematocrit (HCT): Polycythemia is considered when the hematocrit is greater than 48% in women and 52% in men.
  • Hemoglobin (HGB): Polycythemia is considered when a hemoglobin level of greater than 16.5g/dL in women or hemoglobin level greater than18.5 g/dL in men.

Polycythemia can be divided into two categories; primary and secondary.

  • Primary polycythemia: In primary polycythemia the increase in red blood cells is due to inherent problems in the process of red blood cell production.
  • Secondary polycythemia: Secondary poly...

Read the Polycythemia (High Red Blood Cell Count) article �


Source: http://www.medicinenet.com/guide.asp?s=rss&a=399&k=Womens_Health_General

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The Dangers Of Snow Shoveling

Main Category: Heart Disease
Also Included In: Men's health;��Public Health
Article Date: 28 Nov 2011 - 0:00 PST

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Current Article Ratings:


Patient / Public: 3 stars

3 (1 votes)

Healthcare Prof: 3 stars

3 (1 votes)


Urban legend warns shoveling snow causes heart attacks, and the legend seems all too accurate, especially for male wintery excavators with a family history of premature cardiovascular disease. However, until recently this warning was based on anecdotal reports.

Two of the most important cardiology associations in the US include snow -shoveling on their websites as a high risk physical activity, but all the citation references indicate that this warning was based one or two incidents.

"We thought that this evidence should not be enough to convince us that snow-shoveling is potentially dangerous, " says Adrian Baranchuk, a professor in Queen's School of Medicine and a cardiologist at Kingston General Hospital.

Dr. Baranchuk and his team retrospectively reviewed KGH patient records from the two previous winter seasons and discovered that of the 500 patients who came to the hospital with heart problems during this period, 7 per cent (35 patients) had started experiencing symptoms while shoveling snow.

"That is a huge number," says Dr. Baranchuk. "7 per cent of anything in medicine is a significant proportion. Also, if we take into account that we may have missed some patients who did not mention that they were shoveling snow around the time that the episode occurred, that number could easily double."

The team also identified three main factors that put individuals at a high risk when shoveling snow. The number one factor was gender (31 of the 35 patients were male), the second was a family history of premature coronary artery disease (20 of the 35 patients), and the third was smoking (16 out of 35 patients). The second two factors may carry much more weight than the first, however, since the team could not correct for high rate of snow shoveling among men in their sample.

A history of regularly taking four or more cardiac medications was found to be preventative.

Dr. Baranchuk collaborated on this study with Wilma Hopman (Department of Community Health and Epidemiology, KGH Clinical Research Centre), William McIntyre, (Queen?s medical resident), and Salina Chan and David Schogstad-Stubbs (Queen?s medical students).
These findings were recently published in Clinical Research in Cardiology.
Queen's University
Please use one of the following formats to cite this article in your essay, paper or report:

MLA

Queen's University. "The Dangers Of Snow Shoveling." Medical News Today. MediLexicon, Intl., 28 Nov. 2011. Web.
30 Nov. 2011. <http://www.medicalnewstoday.com/releases/238210.php>


APA

Please note: If no author information is provided, the source is cited instead.


Rate this article:
(Hover over the stars then click to rate)
Patient / Public:
or Health Professional:

Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.


Source: http://www.medicalnewstoday.com/releases/238210.php

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Rare syndrome 'may give autism clues'

?A rare syndrome linked to autism could help explain the origins of the condition,? BBC News reported. The broadcaster said that in the search for clues about autism, scientists have examined a rare condition called Timothy syndrome, which can cause autistic behaviour. Although just 20 people are thought to have the condition worldwide, it is of interest because the cause has been pinpointed to a single gene defect.

In a new laboratory study, scientists took skin cells from two people with Timothy syndrome and converted them into nerve cells for use in a series of experiments. They found that the types of nerve cells that developed differed from those in people without Timothy syndrome, and that activity of specific genes varied in these cells.

Although scientists found that one of these differences in gene activity could be reversed by a particular experimental drug in the laboratory, it is unclear whether this would have any practical benefit in people with Timothy syndrome. It is also unclear to what extent the results represent what happens in most autistic spectrum disorders, which are not caused by this syndrome. Overall, further study of the Timothy syndrome nerve cells and animal studies of the syndrome will be needed to understand Timothy syndrome and its implications for autism.

Where did the story come from?

The study was carried out by researchers from Stanford University and other research centres in the US and Japan. It was funded by the US National Institutes of Health, US National Institute of Mental Health, the California Institute for Regenerative Medicine and the Simons Foundation for Autism Research. The study was published in the�peer-reviewed journal Nature Medicine.

This story was covered in a balanced way by BBC News. It explained that Timothy syndrome is a rare cause of autism and included a quote from one of the researchers that put the findings of this exploratory lab research into context.

What kind of research was this?

This laboratory research looked at the effects of an extremely rare condition called Timothy syndrome, which causes a range of problems, including heart rhythm problems, developmental delay, and usually autistic spectrum disorder. People with the condition usually die in childhood from their heart problems. According to the US National Library of Medicine, there are only 20 reported cases of the condition worldwide.

The condition is caused by a mutation in a gene called CACNA1C, which is involved in the production of calcium channels, key protein structures that allow cells to control the flow of electrically charged atoms (ions) into the cells. The flow of calcium ions is involved in a range of important cellular functions, including the generation of electrical signals, cell-to-cell communication and the regulation of certain genes.

The study looked at how the Timothy syndrome mutation affects brain cells, to try to understand how this might lead to autism in the affected individuals. Although most people with autism do not have Timothy syndrome, the researchers hoped that understanding this rare syndrome would shed light on the brain changes that might cause the more common forms of autism. It may also help them eventually identify drugs that could help treat autism, but this would be a longer-term goal.

Laboratory research is the most appropriate way to investigate this type of question, as it would be difficult to do this kind of research in humans.

What did the research involve?

The researchers took skin cells from two people with Timothy syndrome and three people without Timothy syndrome (controls). They used recently developed techniques to ?re-programme? the skin cells to become stem cells in the laboratory. Stem cells are ?building block? cells that can develop into any form of cell in the body. The researchers treated the stem cells in a way that encouraged them to develop into types of nerve cells (neurons) found in the outer region of the human brain, in an area called the cortex. They then studied how the Timothy syndrome-derived nerve cells differed from the normal control nerve cells.

Nerve cells transmit signals using electrical impulses, which they generate by controlling the flow of electrically charged atoms (ions) across the cell?s membrane. Given that Timothy syndrome is caused by a mutation in a gene that produces one protein involved in the transport of calcium ions, the researchers were interested in whether the Timothy syndrome nerve cells performed similarly to control nerve cells, for example in how they sent electrical signals.

The flow of calcium into cells also influences which genes are switched on in the cells, so the researchers also looked at whether this was affected in Timothy syndrome nerve cells. They also looked at whether the nerve cells derived from people with Timothy syndrome were of the same types as the control nerve cells. They did this by looking for genes that are only switched on in specific types of nerve cells. The researchers also used genetically engineered mice carrying the Timothy syndrome mutation to see if their brain cells showed similar effects.

They also investigated the effect of drugs that block the flow of calcium into the cell through the protein channel affected by Timothy syndrome.

What were the basic results?

The researchers found that similar numbers of nerve cells could be obtained from the reprogrammed Timothy syndrome and control stem cells, and that the cells could divide and grow in similar ways. Nerve cells carry messages using electrical impulses, and the Timothy syndrome nerve cells had slightly different electrical properties to control nerve cells. At a specific point during electrical signalling, the Timothy syndrome nerve cells allowed more calcium to flow into them than the control nerve cells did.

The activity of certain genes was also found to differ between the Timothy syndrome nerve cells and the control nerve cells. Of these genes, it had previously been suggested that 11 play a role in autistic spectrum disorders or intellectual disability.

A greater proportion of the Timothy syndrome nerve cells than the control nerve cells were found to resemble the nerves found in the upper layer of the cortex. Also, fewer Timothy syndrome nerve cells were found to resemble the nerves found in the lower layer of the cortex. In particular, the researchers found that fewer of the Timothy syndrome nerve cells switched on a gene called SATB2, which is normally switched on in a specific type of lower layer nerve cell. The researchers also found fewer brain nerve cells producing SATB2 in mice carrying the Timothy syndrome mutation.

More human Timothy syndrome nerve cells switched on a gene called TH, which makes an enzyme that is important for normal signalling between cells in the nervous system. However, this increased TH activity was not found in the brains of mice carrying the Timothy syndrome mutation. During lab tests, the researchers were able to reduce the activity of the TH gene by treating the mice�with a chemical called roscovitine.

How did the researchers interpret the results?

The researchers concluded that their findings provided ?strong evidence? that the CACNA1C gene, which is mutated in Timothy syndrome, normally regulates the development of nerve cells in the cortex of the brain. They say that this offers ?new insights into the causes of autism in individuals with Timothy syndrome?.

Conclusion

This study has furthered researchers? understanding of the effects of the Timothy syndrome mutation on nerve cells in the laboratory. This type of research has been made possible because of recent scientific advances that allow researchers to produce different types of cell, including nerves, from stem cells derived from adult skin cells. This has granted them a supply of nerve cells that do not need to be sourced from people?s brains or from animals. The results may be more representative of what happens in humans than if the researchers only studied cells from mice that were genetically engineered to carry the Timothy syndrome mutation. Studying these individual skin-derived nerve cells is unlikely to be fully representative of the complexities of the developing human brain, but is likely to be the best method currently available.

Importantly, although the experimental drug roscovitine was found to reduce the activity of one gene in nerve cells derived from the skin of people with Timothy syndrome, whether this would produce any practical benefit for people with this syndrome is not known. Much more laboratory and animal research would be needed to assess the potential effects (including side effects) of this or similar drugs before they could be tested on people with this syndrome. It is also worth noting that Timothy syndrome is a very rare cause of autism. It is not clear to what extent these findings apply to more common forms of autism.

Overall, further study of these Timothy syndrome nerve cells and in animal models of the syndrome will be needed to confirm the results and improve our understanding of the condition.

Links To The Headlines

Brain find sheds light on autism. BBC News, November 27 2011

Links To Science

Pa?ca SP, Portmann T, Voineagu I et al. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nature Medicine, November 27 2011 (published online).

Source: http://www.nhs.uk/news/2011/11November/Pages/timothy-syndrome-brain-cell-autism-clue.aspx

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Moderate Alcohol Intake Linked To Lower Female Diabetes Risk

Editor's Choice
Academic Journal
Main Category: Nutrition / Diet
Also Included In: Diabetes;��Alcohol / Addiction / Illegal Drugs;��Women's Health / Gynecology
Article Date: 25 Nov 2011 - 7:00 PST

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Females in middle age who drink alcohol moderately and consume large amounts of refined carbohydrates have a 30% lower chance of developing diabetes type 2, compared to women with similar dietary habits who don't drink, researchers from the Harvard School of Public Health wrote in the American Journal of Clinical Nutrition. Examples of refined carbohydrate foods include sugary drinks, white bread, some pastas, and (polished) white rice.

The authors explained, as background information to their report, that very little prior research has focused on whether there might be an association between glycemic index load, glycemic index, alcohol consumption and diabetes type 2 risk.

Dr. Frank Hu and team set out to determine what impact alcohol intake (or lack of it) might have on diabetes risk in middle aged women whose refined carbohydrate (carb) intake was high. They tracked 81,827 women for 26 years. The women had participated in the Nurses' Health Study and were all free of diabetes type 2 when the study began.

Their cumulative averages of glycemic index, glycemic load, total carb intake and total alcohol intake were calculated every two to four years using questionnaires.

During the follow-up period 6,950 participants developed diabetes type 2.

They found that the women with a high refined-carb intake who consumed moderate amounts of alcohol had a 30% lower chance of developing diabetes type 2 compared to women whose refined-carb intake was also high but consumed no alcohol.

In an interview with Reuters news agency, Dr. Hu said:

"If you eat a high carb diet without drinking alcohol, your risk of developing diabetes is increased by 30 percent.

However, if you eat a high carb diet, but (drink) a moderate amount of alcohol, the increased risk is reduced."

The authors concluded in an Abstract in the journal:

"Our findings suggest that a higher alcohol intake (?15 g/d) attenuates the positive association between GL and T2D incidence."

The moderate drinkers in this study consumed an average of 0.8 once (24 grams) of alcohol each day, the equivalent of approximately two drinks each week. A very small percentage were classed as heavy drinkers - consuming at least two ounces of alcohol each day - they did not have a lower diabetes type 2 risk.

The authors stressed that their study should not encourage people to start drinking if they do not do so now. Rather, they encourage a diet low in refined carbs and high in whole grains. If you are a drinker, they added, you should do so with moderation.

Refined and unrefined grains

Refined grains have been milled so that their outer bran coating has gone, leaving just the endosperm. Examples include white rice, white pasta and white bread. When referring to rice, the term polished is often used with the meaning 'milled'.

Unpolished-rice
Unpolished long-grain rice with bran

Sona-masuri
Polished Indian sona masuri rice grains

In whole grain products, the germ and endosperm are still there. Bran is a good source of fiber, while the germ has protein, minerals and vitamins - the endosperm has carbohydrates (mainly in the form of starch).

Whole grains, also known as unrefined grains (unrefined carbs) are rich in antioxidants and phytochemicals - these help protect us against diabetes, some cancers and coronary heart disease. Some studies have demonstrated that individuals who consume at least three portions of whole grains each day have a lower risk of developing heart disease compared to people who don't.

wholegrain
Here you can see the bran, germ and endosperm

Written by Christian Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Visit our nutrition / diet section for the latest news on this subject.
"Joint association of glycemic load and alcohol intake with type 2 diabetes incidence in women"
Rania A Mekary, Eric B Rimm, Edward Giovannucci, Meir J Stampfer, Walter C Willett, David S Ludwig, and Frank B Hu
Am J Clin Nutr December 2011 ajcn.023754. doi: 10.3945/ajcn.111.023754
Please use one of the following formats to cite this article in your essay, paper or report:

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Christian Nordqvist. "Moderate Alcohol Intake Linked To Lower Female Diabetes Risk." Medical News Today. MediLexicon, Intl., 25 Nov. 2011. Web.
30 Nov. 2011. <http://www.medicalnewstoday.com/articles/238253.php>


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better alcoholic options

posted by selenar on 25 Nov 2011 at 11:39 pm

selecting better alcoholic options is important as well. I have heard there are some low calorie vodkas that can be used for cocktails that contain electrolytes and natural flavors

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Alcohol is not good, in any shape or form

posted by Branden on 26 Nov 2011 at 2:40 am

Alcohol is not good for you one bit, honestly it's not even worth posting the reasons why...Alcohol is not good in any which shape or form...just do not drink

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Source: http://www.medicalnewstoday.com/articles/238253.php

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Paracetamol research is not cause for concern

?Taking too much paracetamol in pills and cold remedies could kill you,? the Daily Mail has today reported. BBC News said researchers have found that even taking slightly too much paracetamol day after day ?can cause overdose?.

People should not be alarmed by this news, which is based on an analysis of over 600 paracetamol users admitted to a Scottish liver transplant unit over a 16-year period. Rather than looking at how often small overdoses caused hospitalisation or death, the research actually looked at the pattern of paracetamol use in those people that ended up needing special liver care after accidental and deliberate paracetamol overdoses.

Crucially, this research does not undermine the fact that paracetamol is a safe and effective painkiller when taken correctly. The research provides valuable information on this specific group of patients, particularly the impact of ?staggered overdose?, when people take two or more paracetamol doses above the recommended level over a period of more than eight hours. Approximately 6 out of every 10 patients in the staggered overdose group survived for 30 days at the clinic, whereas 7 out of 10 survived in a group that had overdosed at single point in time.

While this research does not undermine the safety of paracetamol, it reminds us to always read the label or leaflet that comes with the medication we take and ensure we do not accidentally exceed the recommended dose, especially when taking different medications for different ailments.

Where did the story come from?

The study was carried out by researchers from the University of Edinburgh. It was unclear how this research was funded as the published article states there was no financial support.

The study was published in the peer-reviewed British Journal of Clinical Pharmacology.

What kind of research was this?

This study used information collected over a period of 16 years from a group (or cohort) of patients who were admitted to a Scottish liver unit with paracetamol-induced severe liver injury.

The authors say that the harms caused from paracetamol overdose are the commonest cause of short-term liver failure in the UK. However, they say that at present there is still relatively little known about the harms of regularly taking slightly too much paracetamol over a prolonged period of time ? a so-called staggered overdose pattern ? and about the effect of delaying going to hospital following an overdose.

This study used hospital admission data on paracetamol overdoses to investigate whether taking a staggered overdose of paracetamol or delaying hospital treatment after an overdose would impact on the risk of death from liver failure or the need for a liver transplant.

The news coverage that stated that ?taking too much paracetamol in pills and cold remedies could kill you? did overemphasise the risk of death as described in this research study. It also quite erroneously suggested that taking paracetamol pills in the instructed way is in itself dangerous. Most coverage failed to reassure the public that sticking to the recommended dose of paracetamol is a safe and effective method of pain relief.

What did the research involve?

The researchers studied 938 patients admitted to the Scottish Liver Transplantation Unit over a 16-year period from 1992 to 2008. They attempted to collect detailed information about that patient?s clinical history and medication use, recorded before and after they were admitted to the unit.

Information on paracetamol use was recorded on admission to the transplantation unit by asking the patients to recall their paracetamol use in the last seven days. This included:

  • the number of tablets
  • the type
  • the timing of any overdose
  • any delay to presentation (time between taking an overdose and admission to the transplantation unit)

Paracetamol overdose was defined as the cause of the admission to the transplant unit when there was a clear history of ingesting potentially toxic amounts of paracetamol (greater than 4g/day, the equivalent of eight 500mg tablets) within seven days of being admitted to the unit.

Patients also had to have either a high concentration of paracetamol in their blood (greater than 10mg/L) or elevated levels of enzyme called ALT in the blood without high paracetamol levels. ALT is normally found within the liver cells, and high levels in the blood indicate that it has been released into the bloodstream due to liver cells becoming damaged. Patients with other causes of liver failure, such as viral hepatitis and liver cancer, were excluded from the study.

The researchers then categorised patients by their self-reported paracetamol use. Those who had reported taking taken more than 4g over the course of a single day were labelled as having a ?single time point overdose? (that is, 4g is the equivalent of at least eight standard 500mg tablets).

Patients were labelled as having had a staggered overdose if they had taken two or more paracetamol doses above the recommended level over more than eight hours resulting in a cumulative dose of greater than 4g a day. Those who were admitted to hospital more than 24 hours after taking a paracetamol overdose at a single point of time were classified as having a ?delayed presentation?.

The researchers compared the laboratory blood test results, liver transplant rates and survival of the patients in the different paracetamol groups.

What were the basic results?

Of the 938 patients admitted to the transplant unit, the majority (70.7%) were classified as having paracetamol-induced liver damage. Information on paracetamol use was available for 611 patients; the majority of whom (73.6%) had taken a single point overdose. About one-quarter (26.4%) had taken a staggered overdose. They found that the staggered group had taken significantly less paracetamol than the single point group.

The main finding was that a significantly lower proportion of the staggered overdose group survived 30 days after admittance to the unit (62.7%) when compared to the single overdose group (72.4%). This means that roughly 7 out of 10 survived in the single overdose group survived for 30 days, but only 6 out of every 10 patients in the staggered overdose group.

Compared to single point overdose patients, staggered overdose patients were more likely:

  • to be older
  • to have a history of alcohol abuse
  • to have taken alcohol with their overdose
  • to experience worsening brain function due to liver damage while at the transplant unit
  • require kidney replacement therapy or mechanical ventilation

The group who did not�get to a hospital in less than 24 hours following a single point overdose were more likely to develop worsening brain function due to liver damage during their stay at the transplant unit compared to those who came to hospital earlier.

Information on the reasons for overdose was available for 134 patients. The most common reason given for overdose was for pain relief. Among patients with available data, about one-third (34.3%) of staggered overdoses were taken in deliberate suicide attempts, while accidental overdose was reported in nine cases.

How did the researchers interpret the results?

The authors conclude that patients with staggered paracetamol overdoses had ?reduced survival compared with single overdoses, despite ingestion of lower total amounts of paracetamol?. The researchers also acknowledged that the patients admitted to the transplant unit represented the more severe cases of paracetamol-induced liver disease. They stated that in a standard hospital emergency department the vast majority of paracetamol overdoses will suffer no long-term disease and will not need to be referred to a specialist liver transplant unit.

Conclusion

This study of�938 patients admitted to a liver transplant clinic in Scotland shows that taking a staggered overdose of paracetamol may have a greater adverse effect on survival compared to patients who experience a single point overdose, even though they have ingested less paracetamol overall.

However, while these are certainly valuable results they do not change the fact that paracetamol is a safe and effective painkiller when taken correctly. Instead, the research provides important insight into the outcomes that might occur when paracetamol is not taken in the correct manner, and how different patterns of overuse can affect the body differently.

The study also highlighted the need for people to ensure they take the correct amount, which is always stated on the drug packaging and in the information leaflet inside. It is important to take medication at the recommended dose, so always read the label and seek medical attention if you believe you have taken an overdose.

There are also a number of important strengths and limitations that must be considered when analysing the study?s results. One principal fact to remember is that the people who went to the liver unit do not necessarily represent all people who have overused or overdosed on paracetamol. Also�on their own, the results certainly do not support newspaper suggestions that even a small overdose is likely to kill.

To put the phenomenon into context, these results will have to be considered alongside data quantifying how many people overusing paracetamol actually end up attending hospital for liver problems in the first place. The authors of the research themselves state that the patients at the liver transplant unit represent those most severe cases of paracetamol damage and that ?the vast majority of paracetamol overdoses will suffer no long-term physical damage?.

This study is, however, strengthened by the fact that the Scottish transplant clinic serves all patients in Scotland and so the researchers will have picked up the majority of paracetamol-induced liver failure in Scotland in the last 16 years. On this basis, it provides important information on patients who overdose and require hospital assistance, although obviously not all cases of overdose.

One of the main limitations of this study is that it relied on patients recalling their past paracetamol use accurately and reliably. This may be prone to human error, which could influence the results of the study. Similarly, information on paracetamol use was only available for 611 out of 938 patients admitted to the transplant unit. If this missing information had been included, it may have influenced the results.

In terms of the overall relevance for people taking paracetamol for pain relief, it is worth noting that accidental overdose in the staggered group was reported in only nine individuals. Most patients either knew they were taking too much paracetamol for pain relief or took paracetamol deliberately as part of a suicide attempt (one-third of people).

The average amount of paracetamol taken was high at 24g, or 48 tablets, in the staggered overdose group. However, as little as 10g, or 20 tablets, was reported as the lowest taken by one person who developed liver failure. There was a high proportion (almost 50%) of alcohol abuse in the staggered group, suggesting that alcohol use could play a strong part in determining whether people using too much paracetamol will need to attend hospital.

Links To The Headlines

Paracetamol warning: 'Slightly too much can cause overdose'. BBC News, November 23 2011

A few extra tablets can cause cumulative paracetamol overdose. The Daily Telegraph, November 23 2011

Warning over hidden danger of taking too much Paracetamol. Daily Mail, November 23 2011

Links To Science

Craig DGN, Bates CM, Davidson JS et al. Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity. British Journal of Clinical Pharmacology, 2011

Source: http://www.nhs.uk/news/2011/11November/Pages/staggered-overdose-paracetamol-research.aspx

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[CDC, Office of Women's Health, Health Matters for Women] 10 Ways STDs Impact Women Differently from Men

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Source: http://www2c.cdc.gov/podcasts/download.asp?af=h&f=8621170

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